Tetrahydrocannabivarin (THCV): A Cannabinoid Fighting Obesity

What Is Tetrahydrocannabivarin (THCV)?

As the name might suggest, tetrahydrocannabivarin (THCV) is very similar to the most famous cannabinoid,tetrahydrocannabinol (THC); THCV is like THC’s propyl cannabinoid cousin. Their chemical structure is nearly identical, but the process involved in their creation is slightly different.

Unlike THC, cannabidiol (CBD), and cannabichromene (CBC), THCV doesn’t begin as cannabigerolic acid (CBGA). Instead of combining with olivetolic acid to create CBGA, the geranyl phosphate joins forces with divarinolic acid, which has 2 less carbon molecules. The result is cannabigerovarin acid (CBGVA).

Once CBGVA is created, the process continues exactly same as it would for THC. CBGVA is broken down totetrahydrocannabivarin carboxylic acid (THCVA) by the THCV synthase. At that point, THCVA can be decarboxylated with heat or UV light to create THCV.

The Benefits Of THCV

The relationship between THC and THCV is obvious in the effects as well. Although both cannabinoids effect the same receptors, they do so in a different manner. THCV is actually an antagonist of the CB1 and CB2 receptors, and is being studied for its use as an appetite suppressant.

THCV helps curb your appetite. It is likely one of the reasons why cannabis users are slimmer on average.

Researchers have already found a relation between the endocannabinoids and appetite. Expanding on these findings, they are interested in the potential for THCV to aid in fighting obesity. It’s believed that it blocks the rewarding sensations we experience when eating, often unhealthy, comfort foods.

Not only can THCV help you fit into that new pair of jeans, but it also has anti-convulsive properties. THCV seems to raise the seizure threshold for those with epilepsy. As a result, they experience less seizures.

High-THCV Strains Are Considered To Be Euphoric

Although tetrhydrocannabivarin does affect the same receptors in the brain as THC, it produces a much different high. THCV is psychoactive, but causes more of a psychadelic, clear-headed effect. It causes the effects of THC to hit you much faster, and some think it could be the reason for those “1 hitter quitter” strains. With that said, the THC effects also die off a bit more quickly with the presence of THCV.

A search for strains high in THCV at your local collective would certainly be rewarded. Some of the most beloved Sativas in the world are high in THCV. It is most prominent in African landraces, like Durban Poison,and the haze strains. Some breeders have started to focus on the production of more high-THCV strains, and more like TGA Genetics‘ Jack The Ripper would be a great addition.


Read the full article at Medical Jane.

No Guns for Medical Marijuana Users

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Even though medical marijuana is legal in California, it is illegal for users to buy firearms because the federal government considers it a controlled substance. (Published Friday, Sept. 30, 2011)
Federal law states it is illegal to possess a firearm if you use a controlled substance. Marijuana — even medical marijuana — is considered a controlled substance.
In a response to multiple gun dealers, the Bureau of Alcohol, Tobacco, Firearms and Explosives explained, “There are no exceptions in federal law for marijuana purportedly used for medicinal purposes, even if such use is sanctioned by state law.”
Sixteen states, including California have legalized medical marijuana. The state has issued almost 57,000 medical marijuana cards, according to the California Department of Public Health.
Gun rights advocates and medical marijuana advocates are saying this policy is a violation of the second amendment right to keep and bear arms.
Licensed gun dealers cannot sell a gun or ammunition to anyone that indicates on the paperwork that they are using a controlled substance, or if the dealer has a “reasonable cause to believe” person uses drugs. Reasonable cause includes even talking about drugs.
In an interview with the Associated Press, Gary Marbut with the Montana Shooting Sports Association said this puts an unreasonable burden on gun dealers to police their customers.
“Their business is to be merchants, not to be cops. Unfortunately, the federal licensing scheme complicates that. It sounds as if the (ATF) is expecting them to drift further into the cop role,” Marbut said.
The Justice Department however believes that part of the responsibility of selling guns is to keep them away from people who are prohibited from having them.


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